Dragons, black swans and decisions

Yield of Black Swans

h EXCEPT FOR GETTING your chip to market on time, optimizing yield is perhaps the most important thing we can do to improve IC profitability. We address this problem in several ways: design for manufacturability (DFM) through layout rules, process control, and increasingly clean cleanrooms. In an ideal world, this would solve our yield problems. We know it doesn’t, so we build a diagnostic capa...

Black Swans and white tablets

The Black Swan, a metaphor for highly improbable, high impact events, warns us to understand the limits of our predictions and expect the “unknown unknowns” everywhere, from war to science and industry. From the earliest stages of discovery to post-marketing events, we argue that fundamentally the structure of pharmaceutical industry is driven by and impacted by both positive and negative Black...

Waiting for medicine's black swans.

Free Will, Black Swans and Addiction

The current dominant perspective on addiction as a brain disease has been challenged recently by Marc Lewis, who argued that the brain-changes related to addiction are similar to everyday changes of the brain. From this alternative perspective, addictions are bad habits that can be broken, provided that people are motivated to change. In that case, autonomous choice or "free will" can overcome ...

Black Swans and the Domains of Statistics

The Black Swan: The Impact of the Highly Improbable (hence TBS) is only critical of statistics, statisticians, or users of statistics in a very narrow (but consequential) set of circumstances. It was written by a veteran practitioner of uncertainty whose profession (a mixture of quantitative research, derivatives pricing, and risk management) estimates and deals with exposures to higher order s...